Serpina12^tm1Jwada
Targeted Allele Detail

Summary

• Symbol: Serpina12^tm1Jwada
• Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12; targeted mutation 1, Jun Wada
• MGI ID: MGI:5568548
• Gene: Serpina12 Location: Chr12:103995028-104010702 bp, - strand Genetic Position: Chr12, 53.05 cM, cytoband F1
• Alliance: Serpina12^tm1Jwada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208508
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of expression in the serum of mice fed a high fat, high sucrose diet. (J:208508)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpina12 Mutation: 34 strains or lines available

References

• Original: J:208508 Nakatsuka A, et al., Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes. 2012 Nov;61(11):2823-32
• All: 3 reference(s)