Akr1b7^tm1.1Anm
Targeted Allele Detail

Summary

• Symbol: Akr1b7^tm1.1Anm
• Name: aldo-keto reductase family 1, member B7; targeted mutation 1.1, Antoine Martinez
• MGI ID: MGI:5568561
• Gene: Akr1b7 Location: Chr6:34389297-34400072 bp, + strand Genetic Position: Chr6, 14.95 cM
• Alliance: Akr1b7^tm1.1Anm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed hygromycin resistance cassette was inserted downstream of exon 6. Cre-mediated recombination removed exons 4 through 6 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the adrenal and white adipose tissue (periadrenal and gonadal). (J:208505)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1b7 Mutation: 25 strains or lines available

References

• Original: J:208505 Volat FE, et al., Depressed levels of prostaglandin F2alpha in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity. Diabetes. 2012 Nov;61(11):2796-806
• All: 1 reference(s)