Grb10^tm1.1Fliu
Targeted Allele Detail

Summary

• Symbol: Grb10^tm1.1Fliu
• Name: growth factor receptor bound protein 10; targeted mutation 1.1, Feng Liu
• MGI ID: MGI:5568580
• Gene: Grb10 Location: Chr11:11880499-11987428 bp, - strand Genetic Position: Chr11, 7.15 cM
• Alliance: Grb10^tm1.1Fliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208498
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 3. (J:208498)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb10 Mutation: 56 strains or lines available

References

• Original: J:208498 Zhang J, et al., Disruption of growth factor receptor-binding protein 10 in the pancreas enhances beta-cell proliferation and protects mice from streptozotocin-induced beta-cell apoptosis. Diabetes. 2012 Dec;61(12):3189-98
• All: 4 reference(s)