Lats2^tm1.1Jfm
Targeted Allele Detail

Summary

• Symbol: Lats2^tm1.1Jfm
• Name: large tumor suppressor 2; targeted mutation 1.1, James F Martin
• MGI ID: MGI:5568589
• Synonyms: Lats2^f
• Gene: Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
• Alliance: Lats2^tm1.1Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170963
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 5 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the neo cassette. (J:101977)

Expression

In Mice Carrying this Mutation:

48 assay results 6 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Lats2^tm1.1Jfm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats2 Mutation: 44 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 52 reference(s)