Tnfrsf9^em2Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfrsf9^em2Ygch
• Name: tumor necrosis factor receptor superfamily, member 9; endonuclease-mediated mutation 2, Yi-Guang Chen
• MGI ID: MGI:5568601
• Gene: Tnfrsf9 Location: Chr4:151004612-151030561 bp, + strand Genetic Position: Chr4, 81.52 cM
• Alliance: Tnfrsf9^em2Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtDvs

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger nuclease technology was used to target exon 4. Founder line 12 contains a 2 bp deletion (CTCCAG to CCAG) that introduces a premature stop codon. Flow cytometry confirmed the absence of protein expression on T cells. (J:208927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf9 Mutation: 49 strains or lines available

References

• Original: J:208927 Chen YG, et al., Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014 Jan;63(1):68-74
• All: 2 reference(s)