Il17re^tm1Sdl
Targeted Allele Detail

Summary

• Symbol: Il17re^tm1Sdl
• Name: interleukin 17 receptor E; targeted mutation 1, Steven D Levin
• MGI ID: MGI:5568616
• Gene: Il17re Location: Chr6:113435659-113447719 bp, + strand Genetic Position: Chr6, 52.76 cM
• Alliance: Il17re^tm1Sdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178966
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 to exon 6 was replaced with beta-galactosidase-encoding sequence followed by a phosphoglycerate kinase-neomycin-resistance selection cassette that was inserted into exon 1, in-frame with the original ATG start codon. (J:178966)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Il17re^tm1Sdl/Il17re^tm1Sdl	involves: C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
immune system	√
increased susceptibility to bacterial infection	√
increased susceptibility to bacterial infection induced morbidity/mortality	√
mortality/aging	√
increased susceptibility to bacterial infection induced morbidity/mortality	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17re Mutation: 36 strains or lines available

References

• Original: J:178966 Song X, et al., IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol. 2011 Dec;12(12):1151-8
• All: 2 reference(s)