Tg(Ins2-GP)#Psoh
Transgene Detail

Summary

• Symbol: Tg(Ins2-GP)#Psoh
• Name: transgene insertion, Pamela Ohashi
• MGI ID: MGI:5568709
• Synonyms: LCMV GP, RIP-gp
• Transgene: Tg(Ins2-GP)#Psoh Location: unknown
• Alliance: Tg(Ins2-GP)#Psoh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The pancreas-specific rat insulin II promoter drives the expression of the lymphocytic choriomeningitis viral glycoprotein. Exons 2 and 3 of the beta-globin gene were ligated to the 3' end of the construct to provide splicing and polyadenylation signals. Immunohistochemistry confirmed protein expression in the pancreas. Two lines were established, Bln and Brx. However, the pound symbol (#) is used because the lines are pooled. (J:81285)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:81285 Ohashi PS, et al., Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 1991 Apr 19;65(2):305-17
• All: 12 reference(s)