Bmpr2^tm1.1Pley
Targeted Allele Detail

Summary

• Symbol: Bmpr2^tm1.1Pley
• Name: bone morphogenetic protein receptor type 2; targeted mutation 1.1, Patricio A Leyton
• MGI ID: MGI:5568728
• Synonyms: Bmpr2^deltatd
• Gene: Bmpr2 Location: Chr1:59802721-59917240 bp, + strand Genetic Position: Chr1, 30.44 cM, cytoband C2
• Alliance: Bmpr2^tm1.1Pley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209027
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Reporter) Mutations: Insertion, Intragenic deletion Mutation details: An EGFP gene with a stop codon was fused to exon 11. Exon 12 was replaced with a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the expression of a smaller than normal protein (~100 kDa). However, cell membrane localization of the truncated protein is normal. (J:209027)

Generation of the Bmpr2^tm1.1Pley allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmpr2 Mutation: 46 strains or lines available

References

• Original: J:209027 Leyton PA, et al., Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. PLoS One. 2013;8(10):e76947
• All: 1 reference(s)