Tg(LTF-EGFP/cre/PGR)15Klin
Transgene Detail

Summary

• Symbol: Tg(LTF-EGFP/cre/PGR)15Klin
• Name: transgene insertion 15, Kurt Lin
• MGI ID: MGI:5568730
• Synonyms: Lf-GCrePR1e, Tg(LTF-EGFP/Cre/PR1e)15Klin
• Transgene: Tg(LTF-EGFP/cre/PGR)15Klin Location: unknown
• Alliance: Tg(LTF-EGFP/cre/PGR)15Klin page

Transgene origin

• Strain of Origin: FVB/NJNarl

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(LTF-EGFP/cre/PGR)15Klin expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  LTF (4057)

  Ltf	(MGI:96837)

• Mutation details: A construct was generated with a triple-fusion sequence EGFP/cre/PGR (encoding EGFP, cre recombinase, and the human progesterone ligand binding domain - aa F642-L901 of LBD). The fusion gene was cloned downstream of the human lactoferrin promoter (LTF). The LfB-GCrePR1e construct was used for microinjection and 12 founders were obtained. Four founders (#'s 7, 11, 15, and 27) were crossed to R26-lacZ reporter mice. Line 15 was used to generate most of the results in the original study. (J:209793)

Structure of Tg(LTF-EGFP/cre/PGR)15Klin.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	LTF (human) Summary of all recombinase alleles driven by LTF. Comparative matrix view of recombinase activities Alliance human LTF gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209793 Chen MR, et al., RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice. Genesis. 2010 Oct 1;48(10):585-95
• All: 1 reference(s)