Mesd^tm2.1Bch
Targeted Allele Detail

Summary

• Symbol: Mesd^tm2.1Bch
• Name: mesoderm development LRP chaperone; targeted mutation 2.1, Bernadette C Holdener
• MGI ID: MGI:5568739
• Synonyms: Mesd-LoxP
• Gene: Mesd Location: Chr7:83533074-83549519 bp, + strand Genetic Position: Chr7, 48.35 cM
• Alliance: Mesd^tm2.1Bch page

The Mesd^tm2.1Bch allele does not complement the Mesd^tm1Bch and Tyr^c-3YPSd alleles

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209024
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1, An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. (J:209024)

Generation of the Mesd^tm2Bch and Mesd^tm2.1Bch alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mesd Mutation: 15 strains or lines available

References

• Original: J:209024 Taibi AV, et al., Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues. PLoS One. 2013;8(10):e75782
• All: 1 reference(s)