Rel^tm1Ukl
Targeted Allele Detail

Summary

• Symbol: Rel^tm1Ukl
• Name: reticuloendotheliosis oncogene; targeted mutation 1, Ulf Klein
• MGI ID: MGI:5568752
• Gene: Rel Location: Chr11:23686847-23720969 bp, - strand Genetic Position: Chr11, 14.36 cM
• Alliance: Rel^tm1Ukl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228566
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette was inserted upstream of exon 1 of the targeted gene, and another loxP site followed by the PGK promoter was inserted downstream of exon 1. The entire targeted region was flanked by FRT sites. (J:228566)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rel Mutation: 45 strains or lines available

References

• Original: J:228566 Heise N, et al., Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappaB transcription factor subunits. J Exp Med. 2014 Sep 22;211(10):2103-18
• All: 12 reference(s)