Pip4k2a^tm1.2Lca
Targeted Allele Detail

Summary

• Symbol: Pip4k2a^tm1.2Lca
• Name: phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; targeted mutation 1.2, Lewis C Cantley
• MGI ID: MGI:5568930
• Synonyms: PIP4K2A^-
• Gene: Pip4k2a Location: Chr2:18847066-19002937 bp, - strand Genetic Position: Chr2, 12.93 cM
• Alliance: Pip4k2a^tm1.2Lca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked exon 2 was removed by mating with Ella Cre-deleter mice. Western blot analysis of brain tissue confirmed absence of protein. (J:205288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip4k2a Mutation: 16 strains or lines available

References

• Original: J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57
• All: 3 reference(s)