Hspb1^tm1.1Jdn
Targeted Allele Detail

Summary

• Symbol: Hspb1^tm1.1Jdn
• Name: heat shock protein 1; targeted mutation 1.1, Jonathan Dean
• MGI ID: MGI:5568935
• Synonyms: hspB1^del
• Gene: Hspb1 Location: Chr5:135916773-135918417 bp, + strand Genetic Position: Chr5, 75.51 cM
• Alliance: Hspb1^tm1.1Jdn page

Reduced re-epithelialisation, impaired collagen deposition and increased cellular infiltration in Hspb1^tm1.1Jdn/Hspb1^tm1.1Jdn wounds

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209117
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exons 1 through 3 and the selection cassette. (J:209117)

Generation of the Hspb1^tm1.1Jdn allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb1 Mutation: 18 strains or lines available

References

• Original: J:209117 Crowe J, et al., Heat shock protein B1-deficient mice display impaired wound healing. PLoS One. 2013;8(10):e77383
• All: 2 reference(s)