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Setd1btm1.3Afst
Targeted Allele Detail
Summary
Symbol: Setd1btm1.3Afst
Name: SET domain containing 1B; targeted mutation 1.3, A Francis Stewart
MGI ID: MGI:5568945
Synonyms: Setd1bFDC
Gene: Setd1b  Location: Chr5:123280256-123306692 bp, + strand  Genetic Position: Chr5, 62.8 cM
Alliance: Setd1btm1.3Afst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208420
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsAn FRT-flanked stop cassette containing a lacZ reporter, followed by loxP-flanked exon 5 and rox-flanked PGK-hygromycin cassette were inserted. Dre-recombination removed the PGK-hygromycin selection cassette. Flp mediated recombination removed the stop cassette leaving exon 5 floxed. Cre mediated recombination excised exon 5, resulting in frameshift. Western analysis confirmed lost of Setd1b protein. (J:208420)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Setd1b Mutation:  51 strains or lines available
References
Original:  J:208420 Bledau AS, et al., The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development. 2014 Mar;141(5):1022-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory