Tg(Ins1-Cd80)378Psoh
Transgene Detail

Summary

• Symbol: Tg(Ins1-Cd80)378Psoh
• Name: transgene insertion 378, Pamela Ohashi
• MGI ID: MGI:5569013
• Synonyms: B7-1, RIP-B7-1
• Transgene: Tg(Ins1-Cd80)378Psoh Location: unknown
• Alliance: Tg(Ins1-Cd80)378Psoh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins1-Cd80)378Psoh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd80 (MGI:101775)

• Mutation details: The rat insulin 1 promoter drives the expression of the mouse Cd80 cDNA. Three lines were created: 340, 368, and 378. Immunostaining and Northern blot analysis confirmed expression on beta cells but not in other tissues. (J:209714)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209714 Harlan DM, et al., Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3137-41
• All: 4 reference(s)