Drd5^tm1Shay
Targeted Allele Detail

Summary

• Symbol: Drd5^tm1Shay
• Name: dopamine receptor D5; targeted mutation 1, Seiji Hayashizaki
• MGI ID: MGI:5569103
• Synonyms: Drd5^tm1Mok
• Gene: Drd5 Location: Chr5:38476742-38479868 bp, + strand Genetic Position: Chr5, 20.4 cM
• Alliance: Drd5^tm1Shay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209099
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced the coding sequence. Northern blot analysis confirmed the absence of transcript expression. (J:209099)

Generation of the Drd5^tm1Shay allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd5 Mutation: 39 strains or lines available

References

• Original: J:209099 Hayashizaki S, et al., Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice. PLoS One. 2013;8(10):e75975
• All: 2 reference(s)