Htr2c^tm2Jke
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm2Jke
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 2, Joel K Elmquist
• MGI ID: MGI:5569357
• Synonyms: 2C^flox, Htr2c^flox
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm2Jke page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207704
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A targeting vector constructed from a BAC clone containing the Htr2c sequences was used to insert loxP sites into introns 3 and 5 of Htr2c. Cre-mediated recombination will delete exons 4 and 5. (J:207704)

Generation of Htr2c^tm2Jke.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:207704 Berglund ED, et al., Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest. 2013 Dec 2;123(12):5061-70
• All: 4 reference(s)