Igs13^tm1Dolm
Targeted Allele Detail

Summary

• Symbol: Igs13^tm1Dolm
• Name: intergenic site 13; targeted mutation 1, Ricardo Dolmetsch
• MGI ID: MGI:5569502
• Gene: Igs13 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Igs13^tm1Dolm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (from pCAGGS), loxP-frt-neomycin resistance cassette-loxP-frt-loxP sequence and polyA signal at the centromeric end of the coronin actin binding protein 1A locus (Coro1a) gene. The insertion site is 1165 bp centromeric (transcriptionally downstream) of the last exon. (J:210018)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igs13 Mutation: 1 strain or line available

References

• Original: J:210018 Portmann T, et al., Behavioral abnormalities and circuit defects in the Basal Ganglia of a mouse model of 16p11.2 deletion syndrome. Cell Rep. 2014 May 22;7(4):1077-92
• All: 4 reference(s)