Igs14^tm1Dolm
Targeted Allele Detail

Summary

• Symbol: Igs14^tm1Dolm
• Name: intergenic site 14; targeted mutation 1, Ricardo Dolmetsch
• MGI ID: MGI:5569503
• Gene: Igs14 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Igs14^tm1Dolm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a translational stop codon (for all frames), loxP-frt-puromycin resistance cassette-loxP-frt sequence, rabbit b-globin intron, coding sequence mCherry fluorescent protein (with palmitoylation signal for membrane targeting) and polyA signal at the telomeric end of the sialophorin locus (Spn) gene. The insertion site is 3336 bp telomeric (transcriptionally upstream). (J:210018)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igs14 Mutation: 1 strain or line available

References

• Original: J:210018 Portmann T, et al., Behavioral abnormalities and circuit defects in the Basal Ganglia of a mouse model of 16p11.2 deletion syndrome. Cell Rep. 2014 May 22;7(4):1077-92
• All: 4 reference(s)