Msrb3^tm1Hyk
Targeted Allele Detail

Summary

• Symbol: Msrb3^tm1Hyk
• Name: methionine sulfoxide reductase B3; targeted mutation 1, Hwa-Young Kim
• MGI ID: MGI:5569504
• Gene: Msrb3 Location: Chr10:120617001-120735006 bp, - strand Genetic Position: Chr10, 68.75 cM
• Alliance: Msrb3^tm1Hyk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206322
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 7. Western blot analysis confirmed the absence of protein expression in the heart, skeletal muscle and testis. Immunohistochemistry confirmed the absence of protein expression in the organ of Corti. (J:206322)

Disease models

Expression

In Mice Carrying this Mutation:

62 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msrb3 Mutation: 19 strains or lines available

References

• Original: J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
• All: 3 reference(s)