Del(7Coro1a-Spn)1Dolm
Targeted Allele Detail

Summary

• Symbol: Del(7Coro1a-Spn)1Dolm
• Name: deletion, Chr 7, Ricardo Dolmetsch 1
• MGI ID: MGI:5569506
• Synonyms: 16p11^-, 16p11.2
• Gene: Del(7Coro1a-Spn)1Dolm Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(7Coro1a-Spn)1Dolm involves 39 genes/genome features (Gm25333, Gm15676, Coro1a ...) View all
• Mutation details: Two sequential targeting events generated Igs14^tm1Dolm and Igs13^tm1Dolm. Cre-mediated recombination removed both floxed neomycin cassettes creating a deletion that spans 440 kbp region on mouse chromosome 7F3 (between and including Coro1a to Spn); a region highly conserved with the human chromosome 16p11.2 region whose copy number variations are associated with autism spectrum disorders and schizophrenia. (J:210018)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Coro1a-Spn)1Dolm Mutation: 1 strain or line available

References

• Original: J:210018 Portmann T, et al., Behavioral abnormalities and circuit defects in the Basal Ganglia of a mouse model of 16p11.2 deletion syndrome. Cell Rep. 2014 May 22;7(4):1077-92
• All: 1 reference(s)