Tg(CMV-HTT*48Q)BTag
Transgene Detail
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Symbol: |
Tg(CMV-HTT*48Q)BTag |
Name: |
transgene insertion B, Danilo A Tagle |
MGI ID: |
MGI:5569528 |
Synonyms: |
HD48B |
Transgene: |
Tg(CMV-HTT*48Q)BTag Location: unknown
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Alliance: |
Tg(CMV-HTT*48Q)BTag page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CMV-HTT*48Q)BTag expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HTT (3064) |
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Mutation details: The full-length human huntingtin cDNA containing 48 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, B-D, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain, including primary and secondary motor cortices, entorhinal cortex, striatum, hippocampus and cerebellum. Transgene expression in the brain is five times that of endogenous levels.
(J:50173)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:50173 Reddy PH, et al., Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet. 1998 Oct;20(2):198-202 |
All: |
3 reference(s) |
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