Dmdtm1.1Know
Targeted Allele Detail
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Symbol: |
Dmdtm1.1Know |
Name: |
dystrophin, muscular dystrophy; targeted mutation 1.1, Kirk Knowlton |
MGI ID: |
MGI:5569634 |
Synonyms: |
DysKI |
Gene: |
Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
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Alliance: |
Dmdtm1.1Know page
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Decreased susceptibility to coxsackievirus B3 viral infection of the heart in Dmdtm1.1Know/Dmdtm1.1Know mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:207775
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Two point mutations in exon 50 result in the amino acid substitution of proline for lysine at position 2425 (L2425P) and aspartic acid for serine at position 2426 (S2426D). This mutations prevent cleavage by protease 2A. Cre-mediated recombination removed the floxed neomycin resistance cassette.
(J:207775)
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Generation of the Dmdtm1.1Know allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dmd Mutation: |
154 strains or lines available
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Original: |
J:207775 Lim BK, et al., Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec 2;123(12):5146-51 |
All: |
2 reference(s) |
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