Ano1^tm2Jrr
Targeted Allele Detail

Summary

• Symbol: Ano1^tm2Jrr
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 2, Jason Rock
• MGI ID: MGI:5569641
• Synonyms: Ano1^fl
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm2Jrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210158
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxp site was inserted upstream of exon 12. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 12. (J:210158)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 60 strains or lines available

References

• Original: J:210158 Faria D, et al., The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int. 2014 Jun;85(6):1369-81
• All: 16 reference(s)