Tg(TG-RET/CCDC6)42Cled
Transgene Detail

Summary

• Symbol: Tg(TG-RET/CCDC6)42Cled
• Name: transgene insertion 42, Catherine Ledent
• MGI ID: MGI:5569727
• Synonyms: ret/PTC1, RET/PTC1, Tg-PTC1
• Transgene: Tg(TG-RET/CCDC6)42Cled Location: unknown
• Alliance: Tg(TG-RET/CCDC6)42Cled page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TG-RET/CCDC6)42Cled expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCDC6 (8030)

  Ccdc6

  (MGI:1923801)

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: This transgene contained the bovine thyroglobulin (TG) promoter and a fusion product of human RET and human CCDC6, something often found in human papillary thyroid carcinomas. Line 42 was observed to have a high copy number with regards to the transgene. (J:93679)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(TG-RET/CCDC6)42Cled

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93679 Jhiang SM, et al., Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology. 1996 Jan;137(1):375-8
• All: 3 reference(s)