Tg(TG-SV40)#Cled
Transgene Detail

Summary

• Symbol: Tg(TG-SV40)#Cled
• Name: transgene insertion, Catherine Ledent
• MGI ID: MGI:5569755
• Synonyms: bTg-LTSV40, TgAgT, Tg-TAg
• Transgene: Tg(TG-SV40)#Cled Location: unknown
• Alliance: Tg(TG-SV40)#Cled page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contained the bovine thyroglobulin (TG) promoter and expressed the viral SV40 large T antigen and small t antigen. Thirty founder mice were generated. Two transgenic lines were established but neither was specifically named. Immunofluorescence indicates antigen expression in the nuclei of all thyroid cells, but absent in connective or vascular tissue in the thyroid or in other tissues. (J:209788)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TG-SV40)#Cled

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Anaplastic Thyroid Cancer J:209788

References

• Original: J:209788 Ledent C, et al., Thyroid adenocarcinomas secondary to tissue-specific expression of simian virus-40 large T-antigen in transgenic mice. Endocrinology. 1991 Sep;129(3):1391-401
• All: 4 reference(s)