Islr2^tm2.1Ddg
Targeted Allele Detail

Summary

• Symbol: Islr2^tm2.1Ddg
• Name: immunoglobulin superfamily containing leucine-rich repeat 2; targeted mutation 2.1, David D Ginty
• MGI ID: MGI:5569767
• Synonyms: Linx^flox
• Gene: Islr2 Location: Chr9:58103580-58111602 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Islr2^tm2.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced to intron 2 and a FRT-PGK-Neo-pA-FRT-loxP cassette was introduced to exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:210221)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Islr2 Mutation: 24 strains or lines available

References

• Original: J:210221 Mandai K, et al., Linx mediates interaxonal interactions and formation of the internal capsule. Neuron. 2014 Jul 2;83(1):93-103
• All: 1 reference(s)