Elof1^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Elof1^{tm1.1(KOMP)Vlcg}
• Name: ELF1 homolog, elongation factor 1; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5569949
• Synonyms: Elof1^-
• Gene: Elof1 Location: Chr9:22024285-22028468 bp, - strand Genetic Position: Chr9, 8.34 cM
• Alliance: Elof1^{tm1.1(KOMP)Vlcg} page
• IMPC: Elof1 gene page

Elof1^{tm1.1(KOMP)Vlcg}/Elof1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with the expected number of embryos at E7.5 that arrest prior to gastrulation, but no embryos at E9.5. Embryos are smaller at E7.5 with no primitive streak or node.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 13491A-G1
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: Cre-mediated excision of the parental Elof1^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Expression

In Mice Carrying this Mutation:	102 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elof1 Mutation: 5 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 7 reference(s)