Tg(Dmp1-cre)1Btm
Transgene Detail

Summary

• Symbol: Tg(Dmp1-cre)1Btm
• Name: transgene insertion 1, Teresita M Bellido
• MGI ID: MGI:5570152
• Synonyms: DMP1-8kb-Cre
• Transgene: Tg(Dmp1-cre)1Btm Location: unknown
• Alliance: Tg(Dmp1-cre)1Btm page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Dmp1-cre)1Btm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dmp1 (MGI:94910)

• Mutation details: This transgene contains the cre recombinase coding sequence downstream of a 12-kb DNA fragment from the mouse dentin matrix protein 1 (Dmp1) gene containing ~8 kb of 5' flanking sequence, the first exon, the first intron and 17 bp of exon 2. Cre recombinase transcripts are detected in bone of 1-month-old transgenic mice, but not in brain, heart, kidney or skeletal muscle. However, deletion of a loxP-flanked sequence is observed at low levels in brain. RT-PCR analysis of FACS-sorted calvarial cells from neonatal transgenic mice revealed the presence of cre recombinase transcripts only in cells containing high levels of mRNA encoding the osteocyte marker sclerostin (SOST) and low levels of the osteoblast marker keratocan. (J:210294)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dmp1 (mouse) Summary of all recombinase alleles driven by Dmp1. Alliance mouse Dmp1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:210294 Bivi N, et al., Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012 Feb;27(2):374-89
• All: 22 reference(s)