Tg(TG-NRAS*Q61K)#Msnt
Transgene Detail

Summary

• Symbol: Tg(TG-NRAS*Q61K)#Msnt
• Name: transgene insertion, Massimo Santoro
• MGI ID: MGI:5570240
• Synonyms: N-ras(Gln61Lys), Tg-N-ras
• Transgene: Tg(TG-NRAS*Q61K)#Msnt Location: unknown
• Alliance: Tg(TG-NRAS*Q61K)#Msnt page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TG-NRAS*Q61K)#Msnt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NRAS (4893)

  Nras	(MGI:97376)

  Expresses human NRAS carrying a Q61K (Gln61Lys) mutation

• Mutation details: This transgene contained the bovine thyroglobulin (TG) promoter and expressed human NRAS carrying a Q61K (Gln61Lys) point mutation. No data was given on the number of founders or number of transgenic lines established. (# - line not specified) (J:210016)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:210016 Vitagliano D, et al., Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas. Oncogene. 2006 Aug 31;25(39):5467-74
• All: 2 reference(s)