Ptges^tm1.1Gaf
Targeted Allele Detail

Summary

• Symbol: Ptges^tm1.1Gaf
• Name: prostaglandin E synthase; targeted mutation 1.1, Garret FitzGerald
• MGI ID: MGI:5570356
• Synonyms: mPGES-1-flox
• Gene: Ptges Location: Chr2:30779483-30793309 bp, - strand Genetic Position: Chr2, 21.75 cM
• Alliance: Ptges^tm1.1Gaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210141
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:210141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptges Mutation: 48 strains or lines available

References

• Original: J:210141 Chen L, et al., Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013 Jan 15;127(2):233-43
• All: 3 reference(s)