Adam17^tm1.2Wesh
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1.2Wesh
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1.2, Wei Shi
• MGI ID: MGI:5571392
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1.2Wesh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 3 and the neomycin resistance cassette. Immunostaining confirmed the absence of protein expression in the lungs. (J:210193)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 64 strains or lines available

References

• Original: J:210193 Xu W, et al., TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L953-63
• All: 1 reference(s)