Ahr^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1.2Arte
• Name: aryl-hydrocarbon receptor; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:5571477
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with the floxed human cDNA spanning exons 3 through 11. Flp-mediated recombination removed the selection marker. Cre-mediated recombination removed the human cDNA. Western blot analysis confirmed the absence of protein expression in the testis, epididymis, caudal sperm and liver. (J:210360)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:210360 Hansen DA, et al., The aryl hydrocarbon receptor is important for proper seminiferous tubule architecture and sperm development in mice. Biol Reprod. 2014 Jan;90(1):8
• All: 15 reference(s)