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Herpud1tm1Kame
Targeted Allele Detail
Summary
Symbol: Herpud1tm1Kame
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; targeted mutation 1, Koichi Kokame
MGI ID: MGI:5571583
Gene: Herpud1  Location: Chr8:95113066-95122005 bp, + strand  Genetic Position: Chr8, 46.46 cM, cytoband C5
Alliance: Herpud1tm1Kame page
Decreased cerebral infarction size in Herpud1tm1Kame/Herpud1tm1Kame mice following temporary three-vessel occlusion

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210654
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES, lacZ and neomycin resistance cassette replaced exons 2 through 8. Western blot analysis confirmed the absence of protein expression in the liver, pancreas and kidney. (J:210654)
Generation of the Herpud1tm1Kame allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Herpud1 Mutation:  30 strains or lines available
References
Original:  J:210654 Eura Y, et al., Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory