Derl1^tm1Kame
Targeted Allele Detail

Summary

• Symbol: Derl1^tm1Kame
• Name: Der1-like domain family, member 1; targeted mutation 1, Koichi Kokame
• MGI ID: MGI:5571584
• Gene: Derl1 Location: Chr15:57732898-57755814 bp, - strand Genetic Position: Chr15, 24.06 cM, cytoband D2
• Alliance: Derl1^tm1Kame page

Developmental delay in E8.5 Derl1^tm1Kame/Derl1^tm1Kame embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210654
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exon 1. Western blot analysis confirmed he absence of protein expression in E7.5 embryos. (J:210654)

Generation of the Derl1^tm1Kame allele

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Derl1 Mutation: 12 strains or lines available

References

• Original: J:210654 Eura Y, et al., Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298
• All: 1 reference(s)