Spic^tm2Kmm
Targeted Allele Detail

Summary

• Symbol: Spic^tm2Kmm
• Name: Spi-C transcription factor (Spi-1/PU.1 related); targeted mutation 2, Kenneth Murphy
• MGI ID: MGI:5572011
• Synonyms: Spic^igfp
• Gene: Spic Location: Chr10:88511131-88518885 bp, - strand Genetic Position: Chr10, 44.14 cM, cytoband C
• Alliance: Spic^tm2Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210804
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert an internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (EGFP) sequence, and a loxP-flanked neomycin (neo) resistance cassette downstream of the stop codon. The endogenous coding sequence is not disrupted. (J:210804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spic Mutation: 24 strains or lines available

References

• Original: J:210804 Haldar M, et al., Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34
• All: 1 reference(s)