Atp1a3^tm1.1Kwk
Targeted Allele Detail

Summary

• Symbol: Atp1a3^tm1.1Kwk
• Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide; targeted mutation 1.1, Kiyoshi Kawakami
• MGI ID: MGI:5572809
• Gene: Atp1a3 Location: Chr7:24677592-24705338 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Atp1a3^tm1.1Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210870
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 6 were replaced with a loxP site, the cDNA fused to EGFP, an FRT-flanked neomycin resistance cassette, a loxP site and STOP/polyadenylation cassette. Cre-mediated recombination removed the fusion cDNA and selection cassette. (J:210870)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a3 Mutation: 70 strains or lines available

References

• Original: J:210870 Ikeda K, et al., Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice. J Physiol. 2013 Jul 1;591(Pt 13):3433-49
• All: 4 reference(s)