Tg(Cma1-cre)#Roer
Transgene Detail

Summary

• Symbol: Tg(Cma1-cre)#Roer
• Name: transgene insertion, Axel Roers
• MGI ID: MGI:5572820
• Synonyms: Mcpt5-Cre
• Transgene: Tg(Cma1-cre)#Roer Location: unknown
• Alliance: Tg(Cma1-cre)#Roer page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cma1-cre)#Roer expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cma1 (MGI:96941)

• Mutation details: This transgene contains a modified BAC RP23-284A14 in which a cre and floxed neo cassette was inserted into exon 1 replacing a portion of the coding region. Cre-mediated deletion was used to remove the neo cassette. Six founder lines were generated one with only 80% of peritoneal mast cells expressing the transgene that was not further examined and two other lines expressing in 100% of peritoneal cells in an autosomal inheritance pattern (line A) and the other in an X-linked inheritance pattern (line X). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:133910)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cma1 (mouse) Summary of all recombinase alleles driven by Cma1. Alliance mouse Cma1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:209168 Abramova A, et al., The transcription factor MAZR preferentially acts as a transcriptional repressor in mast cells and plays a minor role in the regulation of effector functions in response to FcepsilonRI stimulation. PLoS One. 2013;8(10):e77677
• All: 38 reference(s)