Atg5^tm1.1Myok
Targeted Allele Detail

Summary

• Symbol: Atg5^tm1.1Myok
• Name: autophagy related 5; targeted mutation 1.1, Minesuke Yokoyama
• MGI ID: MGI:5572834
• Gene: Atg5 Location: Chr10:44144354-44240287 bp, + strand Genetic Position: Chr10, 23.24 cM
• Alliance: Atg5^tm1.1Myok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205532
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to flank exon 3 with loxP sites. Cre-mediated recombination removes both exon 3 and the selection cassette. (J:205532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg5 Mutation: 29 strains or lines available

References

• Original: J:205532 Wang S, et al., Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013 Nov 7;13(5):617-25
• All: 2 reference(s)