Rgs3^tm1Ndul
Targeted Allele Detail

Summary

• Symbol: Rgs3^tm1Ndul
• Name: regulator of G-protein signaling 3; targeted mutation 1, Nickolai O Dulin
• MGI ID: MGI:5572935
• Synonyms: RGS3^deltaRGS
• Gene: Rgs3 Location: Chr4:62478079-62621256 bp, + strand Genetic Position: Chr4, 33.19 cM
• Alliance: Rgs3^tm1Ndul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 30 through 32, which encode the RGS domain. Western blot analysis confirmed the absence of full-length protein in splenocyte with the expression of a truncated protein. (J:210195)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs3 Mutation: 46 strains or lines available

References

• Original: J:210195 Williams JW, et al., RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L693-701
• All: 1 reference(s)