Tnfrsf1a^tm3.1Gkl
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm3.1Gkl
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 3.1, George Kollias
• MGI ID: MGI:5572949
• Synonyms: Tnfrsf1a^fl, Tnfrsf1a^flx
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm3.1Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. A second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 2 through 5 floxed. (J:210950)

Generation of the Tnfrsf1a^tm3.1Gkl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 52 strains or lines available

References

• Original: J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603
• All: 16 reference(s)