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Tnfrsf1atm4.1(TNFRSF1A)Gkl
Targeted Allele Detail
Summary
Symbol: Tnfrsf1atm4.1(TNFRSF1A)Gkl
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 4.1, George Kollias
MGI ID: MGI:5572951
Synonyms: hTnfrsf1alpha KI
Gene: Tnfrsf1a  Location: Chr6:125326686-125339446 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Tnfrsf1atm4.1(TNFRSF1A)Gkl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210950
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with the corresponding human sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the human sequence. A second loxP site was inserted downstream of exon 5. (J:210950)
Generation of the Tnfrsf1atm4.1(TNFRSF1A)Gkl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  52 strains or lines available
References
Original:  J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory