Tnfrsf1atm4.1(TNFRSF1A)Gkl
Targeted Allele Detail
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Symbol: |
Tnfrsf1atm4.1(TNFRSF1A)Gkl |
Name: |
tumor necrosis factor receptor superfamily, member 1a; targeted mutation 4.1, George Kollias |
MGI ID: |
MGI:5572951 |
Synonyms: |
hTnfrsf1alpha KI |
Gene: |
Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
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Alliance: |
Tnfrsf1atm4.1(TNFRSF1A)Gkl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:210950
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The open reading frame was replaced with the corresponding human sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the human sequence. A second loxP site was inserted downstream of exon 5.
(J:210950)
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Generation of the Tnfrsf1atm4.1(TNFRSF1A)Gkl allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tnfrsf1a Mutation: |
52 strains or lines available
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Original: |
J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603 |
All: |
1 reference(s) |
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