Insm1^tm2.1Cbm
Targeted Allele Detail

Summary

• Symbol: Insm1^tm2.1Cbm
• Name: insulinoma-associated 1; targeted mutation 2.1, Carmen Birchmeier
• MGI ID: MGI:5573162
• Synonyms: Insm1^deltaSNAG
• Gene: Insm1 Location: Chr2:146064021-146066940 bp, + strand Genetic Position: Chr2, 71.33 cM
• Alliance: Insm1^tm2.1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206319
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding the seven N-terminal amino acids was removed and a 3xFLAG-tagg added to the C-terminal. The final allele lacks the self-excising neomycin resistance cassette inserted downstream of the modified coding region. (J:206319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insm1 Mutation: 13 strains or lines available

References

• Original: J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
• All: 1 reference(s)