Tg(Thy1-Snca)1S13Putt
Transgene Detail

Summary

• Symbol: Tg(Thy1-Snca)1S13Putt
• Name: transgene insertion 1S13, Herman van der Putten
• MGI ID: MGI:5573194
• Synonyms: Thy1-malphaSN
• Transgene: Tg(Thy1-Snca)1S13Putt Location: unknown
• Alliance: Tg(Thy1-Snca)1S13Putt page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Snca)1S13Putt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Snca (MGI:1277151)

• Mutation details: Wild-type mouse alpha-synuclein cDNA expression is driven by the Thy1 regulatory sequences. Three lines were created: 1S13, 1S14, and 1S16. This line expresses mRNA and protein levels in the brain that are up to 6-fold above endogenous levels. (J:177661)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:177661 Rieker C, et al., Neuropathology in mice expressing mouse alpha-synuclein. PLoS One. 2011;6(9):e24834
• All: 2 reference(s)