Cdkl5^tm1.1Cogr
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.1Cogr
• Name: cyclin dependent kinase like 5; targeted mutation 1.1, Cornelius Gross
• MGI ID: MGI:5573232
• Synonyms: cKO
• Gene: Cdkl5 Location: ChrX:159567241-159777673 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.1Cogr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209635
• Parent Cell Line: A8 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 4 is flanked by loxP sites, one 806 bp upstream and the second 347 bp downstream of the exon. A FRT-flanked neomycin resistance cassette that followed the second loxP site has been deleted by flp recombinase. (J:209635)

Generation of the Cdkl5^tm1Cogr, Cdkl5^tm1.1Cogr, and Cdkl5^tm1.2Cogr alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 20 strains or lines available

Notes

According to EMMA, the parental ES cell line is A9, although ES cell line A8 was given in the original publication J:209635.

References

• Original: J:209635 Amendola E, et al., Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. PLoS One. 2014;9(5):e91613
• All: 4 reference(s)