Optn^tm1.1Jda
Targeted Allele Detail

Summary

• Symbol: Optn^tm1.1Jda
• Name: optineurin; targeted mutation 1.1, Jonathan D Ashwell
• MGI ID: MGI:5574309
• Gene: Optn Location: Chr2:5025453-5068862 bp, - strand Genetic Position: Chr2, 3.15 cM
• Alliance: Optn^tm1.1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207113
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 12. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exon 12 floxed. (J:207113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Optn Mutation: 48 strains or lines available

References

• Original: J:207113 Munitic I, et al., Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells. J Immunol. 2013 Dec 15;191(12):6231-40
• All: 1 reference(s)