Il15^tm1.1Iku
Targeted Allele Detail

Summary

• Symbol: Il15^tm1.1Iku
• Name: interleukin 15; targeted mutation 1.1, Koichi Ikuta
• MGI ID: MGI:5574316
• Synonyms: IL-15-CFP, IL-15^CFP
• Gene: Il15 Location: Chr8:83058261-83129851 bp, - strand Genetic Position: Chr8, 39.33 cM
• Alliance: Il15^tm1.1Iku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206571
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A ECFP-loxP-neo-loxP cassette was inserted at the start codon on exon 3. Cre-mediated recombinase removed the neo-cassette. Reporter expression is seen in stromal cells in various lymphoid organs. (J:206571)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15 Mutation: 44 strains or lines available

References

• Original: J:206571 Cui G, et al., Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1915-20
• All: 3 reference(s)