Diaph3^tm1.1Sna
Targeted Allele Detail

Summary

• Symbol: Diaph3^tm1.1Sna
• Name: diaphanous related formin 3; targeted mutation 1.1, Shuh Narumiya
• MGI ID: MGI:5574347
• Gene: Diaph3 Location: Chr14:86892803-87378671 bp, - strand Genetic Position: Chr14, 43.95 cM, cytoband D3
• Alliance: Diaph3^tm1.1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205519
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One loxP site was inserted upstream of exon1 and a floxed neomycin resistance cassette was inserted downstream. Exon 1 was subsequently removed by cre excision. (J:205519)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Diaph3 Mutation: 90 strains or lines available

References

• Original: J:205519 Watanabe S, et al., Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013 Nov 27;5(4):926-32
• All: 1 reference(s)