Hprt1^{tm1(CAG-NRIP1)Vcls}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-NRIP1)Vcls}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Vincent Cavailles
• MGI ID: MGI:5574440
• Synonyms: RIPTg
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-NRIP1)Vcls} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211324
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(CAG-NRIP1)Vcls} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NRP1 (8829)

  Nrp1	(MGI:106206)

• Mutation details: A targeting construct inserted into the locus a CAG promoter driving ubiquitous expression of the human NRP1 cDNA. (J:211324)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:211324 Lapierre M, et al., RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest. 2014 May 1;124(5):1899-913
• All: 1 reference(s)