Piezo2^{tm1.1(cre)Apat}
Targeted Allele Detail

Summary

• Symbol: Piezo2^{tm1.1(cre)Apat}
• Name: piezo-type mechanosensitive ion channel component 2; targeted mutation 1.1, Ardem Patapoutian
• MGI ID: MGI:5574478
• Synonyms: Piezo2-EGFP-IRES-Cre, Piezo2^GFP
• Gene: Piezo2 Location: Chr18:63143284-63520254 bp, - strand Genetic Position: Chr18, 35.95 cM, cytoband D3
• Alliance: Piezo2^{tm1.1(cre)Apat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211312
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Piezo2^{tm1.1(cre)Apat} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Piezo2 (MGI:1918781)

• Mutation details: An EGFP-IRES-cre cassette followed by an FRT-flanked neomycin resistance selection cassette and loxP site were inserted at the end of exon 54. Flp-mediated recombination removed the selection cassette. (J:211312)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Piezo2 (mouse) Summary of all recombinase alleles driven by Piezo2. Comparative matrix view of recombinase activities Alliance mouse Piezo2 gene page

Expression

In Mice Carrying this Mutation:

14 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Piezo2 Mutation: 123 strains or lines available

References

• Original: J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
• All: 34 reference(s)